Amino acid and structural variability of Yersinia pestis LcrV protein
نویسندگان
چکیده
منابع مشابه
Structure of the Yersinia pestis tip protein LcrV refined to 1.65 resolution
Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA, IMCA-CAT, Hauptman–Woodward Medical Research Institute, 9700 South Cass Avenue, Argonne, IL 60439, USA, Protein Structure Laboratory, Del Shankel Structural Biology Center, University of Kansas, 2034 Becker Drive, Lawrence, KS 66047, USA, and Department of Microbiology and Immunology, University of Miami, Miami,...
متن کاملSurface of Yersinia pestis: LCRV, F1 Production, Invasion and Oxygen: A Dissertation
Of the eleven species of bacteria that comprise the genus Yersinia of the family Enterobacteriaceae three speCIes are pathogenic for humans. Yersinia pseudotuberculosis and Yersinia enterocolitica usually cause a mild, self-limiting mesenteric lymphadenitis or ileitis. Yersinia pestis causes a highly invasive often fatal disease known as plague. All three elaborate a type three secretion system...
متن کاملGlutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis
Glutathionylation, the formation of reversible mixed disulfides between glutathione and protein cysteine residues, is a posttranslational modification previously observed for intracellular proteins of bacteria. Here we show that Yersinia pestis LcrV, a secreted protein capping the type III secretion machine, is glutathionylated at Cys273 and that this modification promotes association with host...
متن کاملAnti-LcrV antibody inhibits delivery of Yops by Yersinia pestis KIM5 by directly promoting phagocytosis.
LcrV of Yersinia pestis is a major protective antigen proposed for inclusion in subunit plague vaccines. One way that anti-LcrV antibody is thought to protect is by inhibiting the delivery of toxins called Yops to host cells. The present study characterizes the relation between this inhibition and the phagocytosis of the bacteria. J774A.1 cells were infected with Y. pestis KIM5 in the presence ...
متن کاملLcrG-LcrV interaction is required for control of Yops secretion in Yersinia pestis.
Yersinia pestis expresses a set of plasmid-encoded virulence proteins called Yops and LcrV that are secreted and translocated into eukaryotic cells by a type III secretion system. LcrV is a multifunctional protein with antihost and positive regulatory effects on Yops secretion that forms a stable complex with a negative regulatory protein, LcrG. LcrG has been proposed to block the secretion app...
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ژورنال
عنوان ژورنال: Infection, Genetics and Evolution
سال: 2010
ISSN: 1567-1348
DOI: 10.1016/j.meegid.2009.10.003